The 64th Air Refueling Squadron is a part of the 22nd Operations Group, McConnell Air Force Base, Kansas, and is operationally assigned to the 157th Operations Group, 157th Air Refueling Wing.

The aim of the Total Force Integration effort is to integrate regular U.S. Air Force airlift and tanker flying units with existing Air National Guard and U.S. Air Force Reserve wings, with the intention of sharing operations and maintenance functions, increasing active duty access to aircraft to meet steady state operational requirements, and taking advantage of the opportunity to season Air Force personnel with the operational experience located in Air Reserve Components. The squadron was stood up at Pease Air National Guard Base on October 2nd, 2009.